Snail1 Is a Transcriptional Effector of FGFR3 Signaling during Chondrogenesis and Achondroplasias
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A Versatile Transcriptional Effector of Wingless Signaling
lution, as testified by a family member in C. elegans, When an extracellular signal determines the fate of a pop-1 (Lin et al., 1995). Binding of TCFs to DNA results cell, the signal is usually transduced to the nucleus, in bending of the helix (Giese et al., 1992), but by themchanging gene expression. In the case of Wingless (wg) selves, these proteins are poor transcriptional activasignaling ...
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The secreted semaphorin Sema3E controls cell migration and invasiveness in cancer cells. Sema3E-receptor, PlexinD1, is frequently upregulated in melanoma, breast, colon, ovarian and prostate cancers; however, the mechanisms underlying PlexinD1 upregulation and the downstream events elicited in tumor cells are still unclear. Here we show that the canonical RBPjk-dependent Notch signaling cascade...
متن کاملCorrection: PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells
[This corrects the article DOI: 10.1371/journal.pone.0164660.].
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TGFβ and BMP signaling pathways exhibit antagonistic activities during the development of many tissues. Although the crosstalk between BMP and TGFβ signaling pathways is well established in bone development, the relationship between these two pathways is less well defined during cartilage development and postnatal homeostasis. We generated hypomorphic mouse models of cartilage-specific loss of ...
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Joints, which separate skeleton elements, serve as important signaling centers that regulate the growth of adjacent cartilage elements by controlling proliferation and maturation of chondrocytes. Accurate chondrocyte maturation is crucial for endochondral ossification and for the ultimate size of skeletal elements, as premature or delayed maturation results predominantly in shortened elements. ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2007
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2007.09.016